tDCS可改善抑郁症伴失眠患者的抑郁和失眠症状
虽然已有不少研究使用经颅直流电刺激（tDCS）治疗重度抑郁症（MDD），但tDCS对同时伴有失眠的MDD患者的疗效尚不清楚。2020年，上海精神卫生中心、宁波市康宁医院、南通大学的研究人员联合开展临床试验，来观察tDCS对伴失眠的MDD患者睡眠质量及抑郁症状的影响，并将研究结果发表在《Sleep Medicine》（IF=4.842）。
采用随机、双盲对照试验，对患有重度抑郁症伴失眠的成年人进行研究。随机分配患者，在常规治疗中加入tDCS或伪tDCS。中国宁波市康宁医院共纳入了90例患者，随机分组后，将47例患者分为tDCS组（Active），43例患者分为伪tDCS组（sham）。tDCS阳极和阴极电极分别放置在左侧和右侧前额叶背外侧区，刺激强度为2mA，每次刺激30分钟，进行20次治疗，共4周。分别于第1天和第28天使用抑郁自评量表（SDS）、焦虑自评量表（SAS）、匹兹堡睡眠质量量表（PSQI）和多导睡眠图（PSG）进行评价。与伪tDCS组比较，tDCS组SAS、SDS总分明显提高。治疗后PSQI总分及PSQI各分项除“睡眠时间和睡眠效率”外均有显著改善。还观察到，通过多导睡眠监测(PSG)，tDCS通过增加总睡眠时间和提高睡眠效率，影响了睡眠结构。研究证明了tDCS对MDD伴失眠患者的睡眠质量和抑郁症状有影响，提示tDCS刺激不仅能改善MDD患者的抑郁和焦虑症状，而且对其睡眠质量有积极的影响。
对于抑郁症伴失眠患者，tDCS刺激可以作为药物很好的补充。
Zhou Qi,Yu Chang,Yu Haihang et al. The effects of repeated transcranial direct current stimulation on sleep quality and depression symptoms in patients with major depression and insomnia.[J] .Sleep Med, 2020, 70: 17-26.
以上内容由依瑞德集团医学中心翻译整理，有不足之处请指正，转载请注明出处。
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